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Why Does Tsunade Look Old? [Solved]
Sakura explained that Tsunade uses the power of the seal to stimulate her special transformation jutsu. You’re right that it isn’t the seal, but if the seal would disappear, the jutsu that transforms her would end right after that. Hence, why she always turns old after losing her Reverse Seal.31 Oct 2014
Why does Tsunade turn into an old woman? #naruto
Info:
10 Things You Didn’t Know About Tsunade Senju (Probably) - Boruto & Naruto
Boruto will be featuring
Tsunade young to old (ft undresse Rehearsal) 
onepiece
